Metanephric nephron morphogenesis

Across TCGA patient cohorts, RNA activity of the Metanephric nephron morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RFLNA, GIMAP6, and MICAL2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Metanephric nephron morphogenesis activity versus RFLNA in PDAC (Pearson r = -0.03).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	RFLNA →	+0.693	+0.495	.008	.008	3	3
CCRCC	GIMAP6 →	-0.536	-0.477	<.001	.001	3	3
GBM	MICAL2 →	-0.528	-0.427	<.001	<.001	3	3
CCRCC	TRIM58 →	-0.241	-0.461	.002	.001	3	3
GBM	ANTXR2 →	-0.581	-0.337	<.001	.006	3	3
CCRCC	LRRC8C →	-0.392	-0.540	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072273 vs RFLNA — PDAC

Explore this scatter interactively →