Metanephric nephron epithelium development

Across TCGA patient cohorts, RNA activity of the Metanephric nephron epithelium development pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SERPINH1, SULF1, and DAPK3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Metanephric nephron epithelium development activity versus SERPINH1 in BRCA (Pearson r = 0.14).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SERPINH1 →	+0.415	+0.036	<.001	.001	3	6
COAD	SULF1 →	+0.541	+0.048	<.001	<.001	3	6
UCEC	DAPK3 →	+0.471	+0.066	.002	.006	3	6
LSCC	ITGAV →	+0.443	+0.055	.001	.001	3	6
UCEC	NID1 →	+0.376	+0.051	<.001	.004	3	6
HNSC	SMAP2 →	-0.240	-0.066	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072243 vs SERPINH1 — BRCA

Explore this scatter interactively →