Metanephric nephron epithelium development

Across TCGA patient cohorts, RNA activity of the Metanephric nephron epithelium development pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C8orf88, CLEC14A, and CD99, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Metanephric nephron epithelium development activity versus C8orf88 in COAD (Pearson r = -0.02).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	C8orf88 →	+0.498	+0.099	.004	.001	3	4
LUAD	CLEC14A →	+0.585	+0.190	<.001	<.001	3	4
LUAD	CD99 →	+0.473	+0.248	.002	<.001	3	4
UCEC	SPON1 →	+1.426	+0.143	.004	.001	3	4
BRCA	DNAJB5 →	+0.475	+0.346	.001	.003	3	4
BRCA	MYLK →	+0.664	+0.447	.009	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072243 vs C8orf88 — COAD

Explore this scatter interactively →