Metanephric nephron epithelium development

Across TCGA cell cohorts, RNA activity of the Metanephric nephron epithelium development pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HSD17B6, S100PBP, and TUT4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HSD17B6 grouped by Metanephric nephron epithelium development-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HSD17B6 →	-1.122	-1.230	.002	<.001	3	5
LARGE_INTESTINE	S100PBP →	-0.680	-1.163	<.001	<.001	3	4
LUNG_NSCLC_LUAD	TUT4 →	-0.719	-0.952	<.001	.002	3	4
LARGE_INTESTINE	PRIMPOL →	-0.472	-0.747	.009	.005	3	4
LARGE_INTESTINE	ZNF644 →	-0.530	-1.040	.008	.003	3	4
LUNG_SCLC	RNF168 →	-0.993	-1.034	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HSD17B6 by Metanephric nephron epithelium development activity — LARGE_INTESTINE

Explore this box plot interactively →