Metanephric nephron epithelium development

Across TCGA cell cohorts, RNA activity of the Metanephric nephron epithelium development pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MTMR3, HDAC10, and HAGHL, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Metanephric nephron epithelium development activity versus MTMR3 in OVARY (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	MTMR3 →	+0.895	+0.262	.001	.008	3	1
OVARY	HDAC10 →	+1.738	+0.229	.006	.001	3	1
OVARY	HAGHL →	+1.998	+0.261	.002	.005	3	1
OVARY	TGFB1 →	+3.882	+0.350	<.001	<.001	3	1
OVARY	CCDC114 →	+0.841	+0.212	.003	.004	3	1
OVARY	TRIM14 →	+1.382	+0.217	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072243 vs MTMR3 — OVARY

Explore this scatter interactively →