Metanephric distal tubule development

Across TCGA patient cohorts, RNA activity of the Metanephric distal tubule development pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ARHGAP15_S64, SEPSECS, and THBS1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Metanephric distal tubule development activity versus ARHGAP15_S64 in BRCA (Pearson r = -0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ARHGAP15_S64 →	-0.910	-0.072	<.001	<.001	3	6
LSCC	SEPSECS →	-0.192	-0.076	<.001	.003	3	6
OV	THBS1 →	+0.786	+0.069	<.001	<.001	3	5
OV	COL12A1 →	+0.581	+0.071	.001	<.001	3	5
CCRCC	ARHGEF6_S684 →	-0.279	-0.073	.008	.001	2	6
BRCA	SPATA2L_S317 →	-0.423	-0.084	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072235 vs ARHGAP15_S64 — BRCA

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