Metanephric distal tubule development

Across TCGA patient cohorts, RNA activity of the Metanephric distal tubule development pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNORD115-47, RNU6-141P, and PARD6BP1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Metanephric distal tubule development activity versus SNORD115-47 in LSCC (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SNORD115-47 →	+0.164	+0.849	.003	<.001	3	3
LSCC	RNU6-141P →	+0.632	+0.691	.003	<.001	3	3
LSCC	PARD6BP1 →	+0.340	+0.528	.003	.001	3	3
LSCC	RPS4XP10 →	+0.465	+0.605	.003	.002	3	3
LSCC	RPL41P2 →	+0.451	+0.700	<.001	<.001	3	3
LSCC	RN7SL246P →	+0.407	+0.560	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072235 vs SNORD115-47 — LSCC

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