Metanephric distal tubule development

Across TCGA cell cohorts, RNA activity of the Metanephric distal tubule development pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VRK1, CHPF, and ECM1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, VRK1 grouped by Metanephric distal tubule development-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	VRK1 →	-1.114	-0.688	<.001	.001	3	4
CNS	CHPF →	+1.525	+1.422	<.001	<.001	3	4
SOFT_TISSUE	ECM1 →	+3.862	+1.511	<.001	.001	3	4
CNS	ZNHIT1 →	+0.653	+0.910	.003	.003	3	4
CNS	PDCD2L →	-0.566	-1.258	.005	.001	3	4
CNS	MMP7 →	+1.054	+0.956	.009	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VRK1 by Metanephric distal tubule development activity — OESOPHAGUS

Explore this box plot interactively →