Metanephric glomerulus development

Across TCGA patient cohorts, RNA activity of the Metanephric glomerulus development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PECAM1, GPIHBP1, and ASPA, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Metanephric glomerulus development activity versus PECAM1 in BRCA (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PECAM1 →	+0.616	+0.441	<.001	.002	3	7
CCRCC	GPIHBP1 →	+1.066	+1.075	<.001	<.001	3	7
BRCA	ASPA →	+0.516	+0.392	<.001	<.001	3	6
BRCA	CNRIP1 →	+0.642	+0.568	.003	.004	3	6
BRCA	RHOJ →	+0.690	+0.637	.003	.001	3	6
CCRCC	CLEC1A →	+0.680	+0.944	.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072224 vs PECAM1 — BRCA

Explore this scatter interactively →