Metanephric glomerular mesangium development

Across TCGA patient cohorts, RNA activity of the Metanephric glomerular mesangium development pathway is significantly associated with the RNA expression of multiple genes, with the LAML cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD34, CLEC14A, and TEK, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Metanephric glomerular mesangium development activity versus CD34 in LAML (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LAML	CD34 →	+2.762	+0.112	<.001	<.001	3	34
TGCT	CLEC14A →	+1.503	+0.111	<.001	<.001	3	34
KICH	TEK →	+1.318	+0.090	<.001	<.001	3	33
TGCT	CD93 →	+1.700	+0.102	<.001	<.001	3	33
PCPG	DIPK2B →	+1.376	+0.125	<.001	<.001	3	33
PCPG	ESAM →	+1.443	+0.123	<.001	<.001	3	33

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072223 vs CD34 — LAML

Explore this scatter interactively →