Metanephric glomerular mesangium development

Across TCGA patient cohorts, RNA activity of the Metanephric glomerular mesangium development pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBP7, CPA3, and PECAM1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Metanephric glomerular mesangium development activity versus RBP7 in CCRCC (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	RBP7 →	+0.903	+0.324	.002	.004	3	4
CCRCC	CPA3 →	+0.954	+0.325	.003	.005	3	4
COAD	PECAM1 →	+0.818	+0.903	<.001	.008	3	4
CCRCC	PLPP1 →	+0.636	+0.218	.001	.005	3	4
UCEC	RAD54B →	-0.397	-0.576	.004	.009	3	4
COAD	CD36 →	+0.909	+0.874	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072223 vs RBP7 — CCRCC

Explore this scatter interactively →