Metanephric glomerular mesangium development

Across TCGA cell cohorts, RNA activity of the Metanephric glomerular mesangium development pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GRHL2, OR52A1, and NGEF, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GRHL2 grouped by Metanephric glomerular mesangium development-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	GRHL2 →	+0.153	+1.147	.005	<.001	3	4
OESOPHAGUS	OR52A1 →	+0.141	+1.219	.003	.001	3	4
LUNG_NSCLC_LUAD	NGEF →	+0.184	+0.779	.001	.008	3	4
CNS	RNF212 →	-0.259	-0.877	.009	.008	3	4
URINARY_TRACT	FZD4 →	+0.150	+1.584	.003	<.001	3	3
SOFT_TISSUE	TNRC6C →	-0.187	-1.358	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GRHL2 by Metanephric glomerular mesangium development activity — BREAST

Explore this box plot interactively →