Regulation of metanephros development

Across TCGA patient cohorts, RNA activity of the Regulation of metanephros development pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BASP1, BASP1_T36, and YRDC_S37, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of metanephros development activity versus BASP1 in GBM (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	BASP1 →	+0.769	+0.132	<.001	<.001	3	7
LSCC	BASP1_T36 →	+0.777	+0.207	<.001	<.001	3	6
PDAC	YRDC_S37 →	+0.417	+0.100	<.001	.007	3	5
CCRCC	ARHGEF26_S392 →	-0.639	-0.101	<.001	<.001	3	5
HNSC	LTBR →	+0.425	+0.261	.002	.003	3	4
LSCC	MPLKIP_S133 →	-0.509	-0.141	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072215 vs BASP1 — GBM

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