Regulation of metanephros development

Across TCGA patient cohorts, RNA activity of the Regulation of metanephros development pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BASP1, P3H3, and DKK3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of metanephros development activity versus BASP1 in CCRCC (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	BASP1 →	+0.850	+0.362	<.001	.006	3	6
CCRCC	P3H3 →	+0.832	+0.287	.001	.003	3	5
HNSC	DKK3 →	+0.718	+0.385	<.001	<.001	3	5
GBM	STMN2 →	+2.076	+0.704	<.001	.001	3	4
GBM	CTIF →	+0.332	+0.483	.001	.005	3	4
GBM	BRSK1 →	+0.595	+0.883	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072215 vs BASP1 — CCRCC

Explore this scatter interactively →