Regulation of metanephros development

Across TCGA cell cohorts, RNA activity of the Regulation of metanephros development pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM184A, RASAL1, and PATJ, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMEM184A grouped by Regulation of metanephros development-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TMEM184A →	-1.920	-1.020	.002	.003	3	5
OVARY	RASAL1 →	-2.784	-1.253	<.001	.001	3	4
OVARY	PATJ →	-1.580	-1.103	.002	.001	2	5
OESOPHAGUS	SPEF2 →	-1.683	-1.219	.001	.001	2	5
LUNG_NSCLC_LUSC	ILRUN →	+0.585	+1.299	.006	.001	3	4
BREAST	KDM5B →	-0.792	-0.924	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMEM184A by Regulation of metanephros development activity — OVARY

Explore this box plot interactively →