Metanephric nephron development

Across TCGA patient cohorts, RNA activity of the Metanephric nephron development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC80, JAM2, and PLN, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Metanephric nephron development activity versus CCDC80 in BRCA (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CCDC80 →	+1.313	+0.737	<.001	<.001	3	5
BRCA	JAM2 →	+0.792	+0.625	<.001	.003	3	5
BRCA	PLN →	+0.897	+0.627	<.001	<.001	3	5
BRCA	FAM124B →	+0.455	+0.619	<.001	.001	3	4
LUAD	CNTN3 →	+0.653	+0.553	.005	.009	3	4
LUAD	PTGIS →	+0.569	+0.639	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072210 vs CCDC80 — BRCA

Explore this scatter interactively →