Metanephric collecting duct development

Across TCGA patient cohorts, RNA activity of the Metanephric collecting duct development pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEPTIN10, RCSD1, and BTN3A1_S327, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Metanephric collecting duct development activity versus SEPTIN10 in LUAD (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SEPTIN10 →	+0.221	+0.086	.008	.001	3	6
HNSC	RCSD1 →	-0.595	-0.085	<.001	<.001	3	5
LSCC	BTN3A1_S327 →	-0.339	-0.077	.007	<.001	3	5
HNSC	FMNL1 →	-0.475	-0.083	<.001	<.001	3	5
LSCC	ARHGAP15_S64 →	-0.798	-0.110	<.001	<.001	3	5
LSCC	PKN1 →	-0.214	-0.075	.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072205 vs SEPTIN10 — LUAD

Explore this scatter interactively →