Metanephric collecting duct development

Across TCGA patient cohorts, RNA activity of the Metanephric collecting duct development pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANXA7, MYOF, and DLG5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Metanephric collecting duct development activity versus ANXA7 in OV (Pearson r = 0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ANXA7 →	+0.418	+0.367	.001	.006	3	4
LSCC	MYOF →	+0.440	+0.488	.002	.001	3	4
BRCA	DLG5 →	+1.292	+0.830	<.001	<.001	3	4
BRCA	IMPDH1P5 →	+0.694	+0.519	.007	.005	3	4
LSCC	TBC1D2 →	+0.694	+0.712	<.001	<.001	3	4
BRCA	IGKV1D-17 →	-1.494	-0.675	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072205 vs ANXA7 — OV

Explore this scatter interactively →