Metanephric collecting duct development

Across TCGA cell cohorts, RNA activity of the Metanephric collecting duct development pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NDFIP1, SDCBP, and JDP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NDFIP1 grouped by Metanephric collecting duct development-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	NDFIP1 →	+0.588	+1.452	.002	<.001	3	4
LUNG_NSCLC_LUAD	SDCBP →	+0.904	+0.744	<.001	<.001	3	4
SOFT_TISSUE	JDP2 →	-2.410	-1.672	.009	<.001	3	4
LUNG_NSCLC_LUSC	TEAD3 →	-1.230	-1.342	.002	<.001	3	4
BONE	BORA →	-0.604	-1.028	.001	.005	3	4
OESOPHAGUS	CFAP157 →	+0.648	+1.898	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NDFIP1 by Metanephric collecting duct development activity — PANCREAS

Explore this box plot interactively →