Metanephric collecting duct development

Across TCGA cell cohorts, RNA activity of the Metanephric collecting duct development pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TEX55, P3H1, and OR56A4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TEX55 grouped by Metanephric collecting duct development-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TEX55 →	-0.289	-0.200	.005	.002	2	5
OESOPHAGUS	P3H1 →	+0.116	+0.194	.001	.004	3	4
OESOPHAGUS	OR56A4 →	-0.176	-0.378	.003	.002	3	4
OVARY	PPP1CB →	-0.325	-0.261	.009	.003	3	4
CNS	RWDD1 →	-0.236	-0.201	<.001	.002	3	4
CNS	VIL1 →	-0.220	-0.148	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TEX55 by Metanephric collecting duct development activity — BREAST

Explore this box plot interactively →