Negative regulation of mesenchymal cell proliferation

Across TCGA patient cohorts, RNA activity of the Negative regulation of mesenchymal cell proliferation pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TGFB1I1, LMNA, and LMNA_S212, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of mesenchymal cell proliferation activity versus TGFB1I1 in CCRCC (Pearson r = 0.06).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TGFB1I1 →	+0.606	+0.837	<.001	<.001	3	6
GBM	LMNA →	+0.493	+0.482	<.001	.003	1	8
UCEC	LMNA_S212 →	+0.689	+0.324	<.001	<.001	3	6
UCEC	LMNA_S22 →	+0.777	+0.255	<.001	<.001	3	6
BRCA	SEPTIN11 →	+0.394	+0.229	<.001	.002	2	6
LUAD	AHNAK →	+0.399	+0.277	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072201 vs TGFB1I1 — CCRCC

Explore this scatter interactively →