Negative regulation of mesenchymal cell proliferation

Across TCGA cell cohorts, RNA activity of the Negative regulation of mesenchymal cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PURB, CDC5L, and MMACHC, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PURB grouped by Negative regulation of mesenchymal cell proliferation-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PURB →	+0.559	+0.623	<.001	.007	3	4
LUNG_SCLC	CDC5L →	+0.543	+0.331	.004	.002	3	4
LARGE_INTESTINE	MMACHC →	+1.002	+0.934	.001	<.001	3	4
LUNG_NSCLC_LUAD	SRF →	+0.641	+0.734	<.001	.002	3	3
LUNG_NSCLC_LUAD	XPO5 →	+0.675	+0.689	<.001	.006	3	3
LUNG_NSCLC_LUAD	C11orf86 →	-1.478	-0.864	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PURB by Negative regulation of mesenchymal cell proliferation activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →