Negative regulation of mesenchymal cell proliferation

Across TCGA cell cohorts, RNA activity of the Negative regulation of mesenchymal cell proliferation pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HSPE1-MOB4, LMAN2L, and SLF1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HSPE1-MOB4 grouped by Negative regulation of mesenchymal cell proliferation-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	HSPE1-MOB4 →	-0.376	-0.243	.001	.001	3	4
SOFT_TISSUE	LMAN2L →	+0.298	+0.276	.008	.009	3	4
SOFT_TISSUE	SLF1 →	+0.300	+0.343	.002	<.001	3	4
SKIN	NPY2R →	-0.179	-0.213	.002	.001	3	3
SKIN	EEF1AKMT2 →	+0.211	+0.215	.008	.001	3	3
SOFT_TISSUE	GSTA2 →	+0.327	+0.321	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HSPE1-MOB4 by Negative regulation of mesenchymal cell proliferation activity — BLOOD_Myeloma

Explore this box plot interactively →