Negative regulation of mesenchymal cell proliferation

Across TCGA cell cohorts, RNA activity of the Negative regulation of mesenchymal cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TP53RK, TXN2, and RBX1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of mesenchymal cell proliferation activity versus TP53RK in LARGE_INTESTINE (Pearson r = -0.89).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TP53RK →	-0.664	-0.293	<.001	.001	3	2
LUNG_SCLC	TXN2 →	-1.026	-1.691	.002	.001	3	1
LUNG_SCLC	RBX1 →	-0.889	-1.691	.002	.001	3	1
LUNG_SCLC	TCL1A →	+0.070	+1.691	<.001	.001	3	1
LUNG_SCLC	UQCC1 →	-0.766	-1.691	<.001	.001	3	1
LUNG_SCLC	MLNR →	-0.180	-1.691	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072201 vs TP53RK — LARGE_INTESTINE

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