Ureter development

Across TCGA patient cohorts, RNA activity of the Ureter development pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CLIC5, EIF4G1, and IFI35, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ureter development activity versus CLIC5 in LSCC (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CLIC5 →	+0.561	+0.062	<.001	<.001	3	6
LSCC	EIF4G1 →	-0.326	-0.063	<.001	<.001	3	6
OV	IFI35 →	-0.361	-0.041	<.001	.001	3	6
OV	APPL1 →	+0.149	+0.040	.004	.001	3	6
CCRCC	ASNS →	-0.573	-0.051	<.001	.001	2	7
BRCA	CAVIN2 →	+0.521	+0.043	.005	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072189 vs CLIC5 — LSCC

Explore this scatter interactively →