Ureter development

Across TCGA patient cohorts, RNA activity of the Ureter development pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AASS, HBP1, and DDAH1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ureter development activity versus AASS in GBM (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	AASS →	+0.641	+0.504	<.001	<.001	3	5
BRCA	HBP1 →	+0.448	+0.617	.002	.002	3	5
BRCA	DDAH1 →	+0.972	+0.619	<.001	.004	3	5
CCRCC	KLF15 →	+1.432	+0.299	<.001	<.001	3	5
GBM	LINC02284 →	+0.569	+0.459	<.001	.005	3	5
BRCA	HADH →	+0.512	+0.600	<.001	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072189 vs AASS — GBM

Explore this scatter interactively →