Ureter development

Across TCGA cell cohorts, RNA activity of the Ureter development pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BMP4, SOX9, and PHLDA1, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ureter development activity versus BMP4 in STOMACH (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	BMP4 →	+4.721	+0.849	<.001	.002	3	13
LUNG_NSCLC_LUSC	SOX9 →	+3.001	+1.603	<.001	<.001	3	11
BONE	PHLDA1 →	+1.858	+0.822	.008	.004	3	8
OESOPHAGUS	PPARGC1B →	-0.903	-1.127	.007	.002	3	8
BREAST	CMTM7 →	+1.833	+0.894	.001	<.001	2	8
BONE	TGFBR2 →	+2.051	+1.191	.008	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072189 vs BMP4 — STOMACH

Explore this scatter interactively →