Nephric duct formation

Across TCGA patient cohorts, RNA activity of the Nephric duct formation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FLNB, RRP1B, and HSPD1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nephric duct formation activity versus FLNB in OV (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	FLNB →	+0.329	+0.117	.006	.002	3	6
HNSC	RRP1B →	-0.188	-0.496	.001	.003	3	6
LSCC	HSPD1 →	-0.475	-0.631	<.001	.001	3	6
PDAC	NCAPG →	-0.432	-0.055	.004	.007	3	6
LUAD	DDX21_S71 →	-1.028	-0.463	.004	.009	3	5
LUAD	TET2_S99 →	-0.644	-0.303	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072179 vs FLNB — OV

Explore this scatter interactively →