Nephric duct formation

Across TCGA cell cohorts, RNA activity of the Nephric duct formation pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRSS16, ASTN2, and MRPS2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRSS16 grouped by Nephric duct formation-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PRSS16 →	-1.213	-0.679	.003	.004	2	6
BREAST	ASTN2 →	+1.017	+0.895	<.001	<.001	3	4
BLOOD_Myeloma	MRPS2 →	+0.820	+1.851	.005	<.001	3	4
BLOOD_Myeloma	EXOSC2 →	+1.244	+1.654	.003	.002	3	4
BLOOD_Myeloma	BEX2 →	-4.312	-2.184	.007	<.001	3	4
OVARY	CDCA7 →	+1.408	+1.191	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRSS16 by Nephric duct formation activity — PANCREAS

Explore this box plot interactively →