Nephric duct morphogenesis

Across TCGA patient cohorts, RNA activity of the Nephric duct morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PACS2, CCDC93_S305, and DOK3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nephric duct morphogenesis activity versus PACS2 in PDAC (Pearson r = 0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PACS2 →	+0.215	+0.074	.001	<.001	3	7
LUAD	CCDC93_S305 →	-0.919	-0.076	<.001	<.001	3	7
UCEC	DOK3 →	-0.403	-0.076	.002	.004	3	6
CCRCC	PTPN1 →	-0.437	-0.085	<.001	<.001	3	6
LUAD	TLN1_S2040 →	+0.562	+0.087	<.001	<.001	3	6
BRCA	DAG1 →	+0.259	+0.070	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072178 vs PACS2 — PDAC

Explore this scatter interactively →