Nephric duct morphogenesis

Across TCGA cell cohorts, RNA activity of the Nephric duct morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BMP4, MAML2, and GPC3, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nephric duct morphogenesis activity versus BMP4 in LUNG_NSCLC_LUSC (Pearson r = 0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	BMP4 →	+4.660	+1.821	<.001	<.001	3	14
PANCREAS	MAML2 →	+1.379	+1.177	.001	<.001	3	8
LIVER	GPC3 →	+4.813	+0.931	.001	.003	3	8
BLOOD_Lymphoma	GATA3 →	+3.104	+1.419	<.001	<.001	3	7
STOMACH	TNNC1 →	+3.351	+1.755	<.001	<.001	3	7
LIVER	KLHDC2 →	+0.915	+1.182	<.001	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072178 vs BMP4 — LUNG_NSCLC_LUSC

Explore this scatter interactively →