Nephric duct development

Across TCGA patient cohorts, RNA activity of the Nephric duct development pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SORBS1, AGO1, and HSPG2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nephric duct development activity versus SORBS1 in BRCA (Pearson r = 0.49).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SORBS1 →	+0.519	+0.056	<.001	<.001	3	6
UCEC	AGO1 →	+0.266	+0.064	<.001	.002	3	6
BRCA	HSPG2 →	+0.665	+0.085	<.001	<.001	3	6
CCRCC	PEBP1 →	+0.376	+0.072	<.001	<.001	3	6
BRCA	PLCD1 →	+0.562	+0.065	<.001	<.001	3	6
PDAC	RIOK2 →	-0.326	-0.088	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072176 vs SORBS1 — BRCA

Explore this scatter interactively →