Nephric duct development

Across TCGA cell cohorts, RNA activity of the Nephric duct development pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DHTKD1, ALDH18A1, and CYB5R2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DHTKD1 grouped by Nephric duct development-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	DHTKD1 →	-1.116	-0.947	.001	.005	3	5
LIVER	ALDH18A1 →	+1.114	+1.345	<.001	<.001	3	4
OESOPHAGUS	CYB5R2 →	-2.762	-1.171	.003	.002	3	4
CNS	PNPLA3 →	-1.380	-1.148	<.001	<.001	3	4
BLOOD_Lymphoma	C22orf23 →	-0.830	-1.677	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	TMEM14C →	-0.777	-0.804	.004	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DHTKD1 by Nephric duct development activity — STOMACH

Explore this box plot interactively →