Nephric duct development

Across TCGA cell cohorts, RNA activity of the Nephric duct development pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CPNE6, MNT, and LUZP4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CPNE6 grouped by Nephric duct development-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CPNE6 →	-0.248	-0.199	<.001	.003	3	5
SOFT_TISSUE	MNT →	-0.297	-0.244	.004	.004	3	5
OVARY	LUZP4 →	-0.160	-0.165	<.001	.007	3	4
STOMACH	ACOT11 →	-0.142	-0.204	.001	<.001	3	4
SOFT_TISSUE	DDX17 →	+0.365	+0.236	.008	.003	3	4
BLOOD_Lymphoma	TSSK1B →	-0.547	-0.235	.002	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CPNE6 by Nephric duct development activity — BLOOD_Leukemia

Explore this box plot interactively →