Metanephric tubule formation

Across TCGA patient cohorts, RNA activity of the Metanephric tubule formation pathway is significantly associated with the RNA expression of multiple genes, with the SARC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SOX9, SOX9-AS1, and CCDC69, each associated with the pathway in up to 24 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Metanephric tubule formation activity versus SOX9 in SARC (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SARC	SOX9 →	+2.621	+0.222	<.001	<.001	3	24
BRCA	SOX9-AS1 →	+0.691	+0.058	<.001	<.001	3	19
THYM	CCDC69 →	-1.176	-0.110	<.001	<.001	3	18
KIRP	LINC02097 →	+0.339	+0.112	<.001	<.001	3	18
ESCA	RAMP3 →	-1.104	-0.083	<.001	<.001	3	16
SARC	AOC3 →	-1.466	-0.126	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072174 vs SOX9 — SARC

Explore this scatter interactively →