Metanephric tubule formation

Across TCGA patient cohorts, RNA activity of the Metanephric tubule formation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RTKN, C18orf54, and TTYH1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Metanephric tubule formation activity versus RTKN in GBM (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RTKN →	+0.647	+0.928	<.001	<.001	3	4
UCEC	C18orf54 →	+0.586	+0.563	<.001	.004	3	4
GBM	TTYH1 →	+0.731	+0.688	<.001	<.001	3	4
GBM	TMCC1 →	+0.319	+0.687	<.001	<.001	3	4
GBM	RAD54B →	+0.428	+0.941	<.001	<.001	3	4
OV	RNF39 →	+0.754	+0.608	.004	.007	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072174 vs RTKN — GBM

Explore this scatter interactively →