Metanephric tubule formation

Across TCGA cell cohorts, RNA activity of the Metanephric tubule formation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SOX9, PAX8, and FRMD5, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Metanephric tubule formation activity versus SOX9 in LUNG_NSCLC_LUSC (Pearson r = 0.87).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	SOX9 →	+3.114	+1.618	<.001	<.001	3	14
OVARY	PAX8 →	+3.571	+0.582	<.001	<.001	3	9
STOMACH	FRMD5 →	+1.509	+1.063	.009	.002	3	8
PANCREAS	PPARG →	+1.914	+0.635	<.001	.003	3	7
LARGE_INTESTINE	TMTC3 →	-0.667	-0.338	<.001	.004	3	7
BREAST	PLAUR →	+1.971	+0.919	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072174 vs SOX9 — LUNG_NSCLC_LUSC

Explore this scatter interactively →