Metanephric tubule morphogenesis

Across TCGA patient cohorts, RNA activity of the Metanephric tubule morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are F2R_S418, PECAM1, and SIPA1_S55, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Metanephric tubule morphogenesis activity versus F2R_S418 in HNSC (Pearson r = -0.14).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	F2R_S418 →	-0.628	-0.067	.004	.005	3	5
GBM	PECAM1 →	-0.371	-0.134	<.001	<.001	3	5
BRCA	SIPA1_S55 →	-0.323	-0.058	<.001	.005	3	5
HNSC	SVIL_S549 →	-0.783	-0.059	<.001	.006	3	5
GBM	TNS3 →	-0.200	-0.076	.007	.006	3	5
GBM	LACTB →	-0.356	-0.106	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072173 vs F2R_S418 — HNSC

Explore this scatter interactively →