Metanephric tubule morphogenesis

Across TCGA patient cohorts, RNA activity of the Metanephric tubule morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are XPO5, ADGRF1, and LINC01559, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Metanephric tubule morphogenesis activity versus XPO5 in GBM (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	XPO5 →	+0.403	+1.029	.001	<.001	3	5
OV	ADGRF1 →	+0.773	+0.516	.002	.002	3	4
OV	LINC01559 →	+0.727	+0.898	.004	<.001	3	4
GBM	GIMAP6 →	-0.733	-0.985	<.001	<.001	3	4
GBM	RASAL3 →	-0.749	-0.986	<.001	<.001	3	4
GBM	IL10RA →	-0.975	-0.942	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072173 vs XPO5 — GBM

Explore this scatter interactively →