Metanephric tubule morphogenesis

Across TCGA patient cohorts, RNA activity of the Metanephric tubule morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SNTB2_S393, SOX9, and BRD3_S263, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Metanephric tubule morphogenesis activity versus SNTB2_S393 in LUAD (Pearson r = -0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SNTB2_S393 →	-0.383	-0.474	<.001	<.001	3	3
BRCA	SOX9 →	+0.575	+0.583	<.001	<.001	2	4
GBM	BRD3_S263 →	+0.367	+0.871	<.001	<.001	3	3
HNSC	FAS_S212 →	-1.111	-0.860	.001	.003	3	3
GBM	AMPD3_S85 →	-0.437	-1.112	<.001	<.001	3	3
LUAD	SOX8 →	+1.324	+0.394	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072173 vs SNTB2_S393 — LUAD

Explore this scatter interactively →