Mesonephric tubule morphogenesis

Across TCGA patient cohorts, RNA activity of the Mesonephric tubule morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEPTIN11, STAT1, and STK10, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mesonephric tubule morphogenesis activity versus SEPTIN11 in PDAC (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SEPTIN11 →	+0.367	+0.043	<.001	<.001	3	7
CCRCC	STAT1 →	-0.526	-0.032	.001	.007	3	7
LSCC	STK10 →	-0.401	-0.054	<.001	<.001	3	7
CCRCC	TAP1 →	-0.552	-0.043	<.001	.001	3	7
BRCA	TAPBP →	-0.493	-0.026	<.001	<.001	3	7
BRCA	ITGAL →	-0.559	-0.021	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072171 vs SEPTIN11 — PDAC

Explore this scatter interactively →