Mesonephric tubule morphogenesis

Across TCGA patient cohorts, RNA activity of the Mesonephric tubule morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MMP16, BBS9, and MEIS3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mesonephric tubule morphogenesis activity versus MMP16 in BRCA (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MMP16 →	+0.899	+0.399	<.001	<.001	3	7
BRCA	BBS9 →	+0.408	+0.278	<.001	.003	3	6
BRCA	MEIS3 →	+1.000	+0.417	.001	<.001	3	6
BRCA	LRRC17 →	+0.993	+0.231	<.001	.001	3	6
COAD	C1QTNF3 →	+0.694	+0.581	<.001	.001	3	6
LSCC	ZNF697 →	+0.732	+0.384	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072171 vs MMP16 — BRCA

Explore this scatter interactively →