Mesonephric tubule morphogenesis

Across TCGA patient cohorts, RNA activity of the Mesonephric tubule morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HIP1, SRPX, and COL1A1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mesonephric tubule morphogenesis activity versus HIP1 in UCEC (Pearson r = 0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HIP1 →	+0.354	+0.338	<.001	<.001	3	4
BRCA	SRPX →	+0.545	+0.291	<.001	<.001	3	4
COAD	COL1A1 →	+0.645	+0.808	<.001	<.001	3	4
COAD	COL1A2 →	+0.701	+0.681	<.001	<.001	3	4
BRCA	DCN →	+0.722	+0.296	<.001	<.001	3	4
COAD	PRKD1 →	+0.426	+0.640	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072171 vs HIP1 — UCEC

Explore this scatter interactively →