Mesonephric tubule morphogenesis

Across TCGA cell cohorts, RNA activity of the Mesonephric tubule morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AHCYL1, ARL6IP1, and MCM2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AHCYL1 grouped by Mesonephric tubule morphogenesis-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	AHCYL1 →	-1.152	-0.258	.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	ARL6IP1 →	-1.746	-0.336	<.001	<.001	3	3
OESOPHAGUS	MCM2 →	+0.835	+0.198	.004	.009	3	3
BONE	RND3 →	-3.520	-1.363	.003	.001	3	3
UPPER_AERODIGESTIVE_TRACT	FAM199X →	-1.083	-0.269	<.001	<.001	3	3
BONE	C22orf15 →	+1.823	+1.198	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AHCYL1 by Mesonephric tubule morphogenesis activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →