Mesonephric tubule morphogenesis

Across TCGA cell cohorts, RNA activity of the Mesonephric tubule morphogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADCY10, KLHL15, and OR2H2, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ADCY10 grouped by Mesonephric tubule morphogenesis-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	ADCY10 →	-0.199	-1.608	.001	.007	3	2
KIDNEY	KLHL15 →	-0.380	-2.110	.006	<.001	3	2
KIDNEY	OR2H2 →	+0.550	+1.909	.007	.002	3	2
KIDNEY	FAM13B →	+0.133	+1.916	.001	<.001	3	2
PANCREAS	STK33 →	-0.095	-2.064	.002	<.001	3	2
BREAST	GABPB1 →	-0.374	-1.394	.004	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ADCY10 by Mesonephric tubule morphogenesis activity — KIDNEY

Explore this box plot interactively →