Mesonephric tubule morphogenesis

Across TCGA cell cohorts, RNA activity of the Mesonephric tubule morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PUS3, ADSL, and ACSF2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mesonephric tubule morphogenesis activity versus PUS3 in OVARY (Pearson r = -0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PUS3 →	-1.133	-1.040	.004	.004	3	3
OESOPHAGUS	ADSL →	-1.616	-2.032	.005	<.001	3	3
KIDNEY	ACSF2 →	+2.926	+2.027	.004	.002	3	3
OESOPHAGUS	KIF11 →	-1.060	-1.986	.001	<.001	2	3
KIDNEY	TMEM255B →	+3.440	+1.896	<.001	<.001	3	2
KIDNEY	PTAR1 →	-1.248	-1.896	.005	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072171 vs PUS3 — OVARY

Explore this scatter interactively →