Epithelial cell fate commitment

Across TCGA patient cohorts, RNA activity of the Epithelial cell fate commitment pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CD248, RPL7, and ZNF800_S317, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Epithelial cell fate commitment activity versus CD248 in OV (Pearson r = 0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CD248 →	+0.658	+0.069	.002	<.001	3	6
OV	RPL7 →	-0.336	-0.086	<.001	<.001	3	5
CCRCC	ZNF800_S317 →	-0.549	-0.112	.002	<.001	3	5
BRCA	COL5A2 →	+0.749	+0.061	<.001	<.001	3	5
CCRCC	COL5A3 →	+0.493	+0.070	<.001	<.001	3	5
CCRCC	EFHD1 →	+0.637	+0.106	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072148 vs CD248 — OV

Explore this scatter interactively →