Epithelial cell fate commitment

Across TCGA patient cohorts, RNA activity of the Epithelial cell fate commitment pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SOCS2, ARHGEF40, and APBB3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Epithelial cell fate commitment activity versus SOCS2 in LSCC (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SOCS2 →	+0.580	+0.405	.001	.008	3	4
UCEC	ARHGEF40 →	+0.467	+0.824	.006	<.001	3	4
BRCA	APBB3 →	+0.550	+0.596	.001	.001	3	4
COAD	LCN2 →	-1.241	-0.656	.002	<.001	3	4
LUAD	CDC14B →	+0.347	+0.766	.004	.008	3	3
OV	LINC02136 →	-0.068	-0.867	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072148 vs SOCS2 — LSCC

Explore this scatter interactively →