Epithelial cell fate commitment

Across TCGA cell cohorts, RNA activity of the Epithelial cell fate commitment pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NUCB1, CAPNS1, and PALLD, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NUCB1 grouped by Epithelial cell fate commitment-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	NUCB1 →	-1.317	-1.940	.001	<.001	3	4
BONE	CAPNS1 →	-0.814	-1.248	.002	.004	3	4
BONE	PALLD →	-4.517	-2.053	<.001	<.001	3	4
BONE	ACTN4 →	-1.897	-1.516	.007	.007	3	4
BONE	EXT2 →	-2.496	-1.756	<.001	.001	3	4
BONE	MMP2 →	-5.484	-1.872	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NUCB1 by Epithelial cell fate commitment activity — BONE

Explore this box plot interactively →