Epithelial cell fate commitment

Across TCGA cell cohorts, RNA activity of the Epithelial cell fate commitment pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACTA1, MAX, and CYP1A2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ACTA1 grouped by Epithelial cell fate commitment-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ACTA1 →	-0.157	-0.162	.002	.004	2	7
BONE	MAX →	-0.526	-0.231	<.001	<.001	3	5
KIDNEY	CYP1A2 →	-0.201	-0.111	.001	.004	3	5
KIDNEY	KCNJ12 →	-0.212	-0.155	.002	<.001	3	5
OVARY	VTI1B →	+0.230	+0.221	.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	ZBTB3 →	-0.175	-0.186	.007	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ACTA1 by Epithelial cell fate commitment activity — PANCREAS

Explore this box plot interactively →